ABSTRACT
Objectives: The French Cancer Plan 2021-2030 targeted to reach 80% of HPV vaccine coverage. The PAPILLON study aimed to monitor HPV VCR from 2017 to 2022 using French National claims database through several indicators: age-specific initiation rates, full schemes, and cumulative VCR. Method(s): All females eligible for HPV vaccine in 2017-2020 were included. Estimations of annual HPV vaccine initiation rates were carried out on 11-14 (target population) and 15-19 year-old females (catch-up). Cumulative VCR at a given age were estimated on girls aged between 11 and 19 at the time of first vaccination. Partial scheme was defined by the dispensing of at least one dose of HPV vaccine, while full scheme was defined by two or three dispensing of doses over an 18-month period, according to current French recommendations. Result(s): During 2017 and 2020, 1,056,288 females received at least one dose of HPV vaccine;the annual initiation rate ranged between 7.7 and 13.4% in 11-14 year-old, and 4.5 and 7.0% in 15-19 year-old;56.9% received a full scheme. Overall, 65.0% of initiations were between 11 and 14 years-old, with a median interval between the first two doses of 188 days (IQR=143 days). In 2020, except for 11-year-old, all initiation rates decreased compared to 2019. Cumulative VCR for full scheme ranged between 15.5% and 24.2% by age 16 and 25.8% and 20.8% by age 20. Conclusion(s): HPV VCR increased between 2017 and 2020, but remains well below target. Interval between doses seems to be well respected, but completion to full scheme remains an issue. The disruption due to COVID19 lockdown was observed in 2020, which highlights the need for catching up on vaccination in these young women and consideration for expansion of age cohort. Many young women them would age out of the current recommendations particularly in the oldest cohorts. Copyright © 2022